Pharmaceutical Sciences

The antidepressant nefazodone inhibits acetylcholinesterase —nefazodone could prevent the progression of Alzheimer’s disease— https://global.toho-u.ac.jp/research/pr-1340/
Platelet activating factor (PAF), a bioactive phospholipid, strongly contracts esophageal smooth muscle. https://global.toho-u.ac.jp/research/pr-1343/
Structure of DNA enzyme that repairs UV-damaged DNA https://global.toho-u.ac.jp/research/pr-1312/
Fibroblast Growth Factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis. https://global.toho-u.ac.jp/research/pr-1316/
Elucidation of the mechanism whereby prostanoid TP receptor stimulation enhances urinary bladder smooth muscle contractions induced by parasympathetic neurotransmitters https://global.toho-u.ac.jp/research/pr-1307/
Elucidation of the mechanism by which platelet-activating factor (PAF) a bioactive phospholipid, enhances detrusor smooth muscle (DSM) contractile activities https://global.toho-u.ac.jp/research/pr1287/
Determination of D– and L-amino acids in black garlic foodstuffs https://global.toho-u.ac.jp/research/pr-1290/
Dimethyl sulfoxide (DMSO), a therapeutic agent for interstitial cystitis with Hannah lesions, enhances urinary bladder smooth muscle contractions induced by acetylcholine —DMSO inhibits acetylcholinesterase activities— https://global.toho-u.ac.jp/research/pr-1269/
Stimulation of α1L-adrenoceptor, atypical α1-adrenoceptor, activates store-operated Ca2+ channels and voltage-dependent Ca2+ channels https://global.toho-u.ac.jp/research/pr-1268/
NCC-3902 shows therapeutic potential against atrial fibrillation by inhibiting delayed sodium channel currents and suppressing electrical activity of the pulmonary vein myocardium https://global.toho-u.ac.jp/research/pr-1267/