Myocardial relaxation dysfunction is a critical heart disease which results in heart failure associated with hypertension, coronary artery disease, and diabetes. However, the crucial need for therapeutic drugs that target this disorder is still unmet. Quercetin, a flavonoid found in fruits and vegetables, has been reported to have antioxidant, antiviral, and anticancer effects. However, the effects of quercetin on myocardial relaxation dysfunction had not been fully investigated.
Interestingly, the research group has shown that quercetin promotes myocardial relaxation in diabetic mice. This effect was attributed to the activation of the calcium pump of the sarcoplasmic reticulum. This finding could lead to the development of new therapeutic drugs derived from natural products, including quercetin.
Journal name: Biological and Pharmaceutical Bulletin, Vol. 44, No. 12, (2021), 1894-1897
Title of paper: Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice
Authors: Shogo Hamaguchi*, Kohei Abe, Momoka Komatsu, Jun Kainuma,
Iyuki Namekata, and Hikaru Tanaka
DOI No.: 10.1248/bpb.b21-00580
Abstract URL: https://doi.org/10.1248/bpb.b21-00580