The natriuretic peptide family consists of ANP, BNP, and CNP. ANP and BNP are hormones secreted by the heart to regulate blood pressure. CNP is a hormone produced in the brain, but its central function remains unclear. A research group led by Dr. Tsukada has shown that CNP genes have diversified during vertebrate evolution. In particular, four CNP genes (CNP1-4) have been found in teleost (compared to one in mammals), suggesting that the hormone is important for brain function in fish. In this presentation, they report the discovery of a fifth CNP gene (CNP4b) in Japanese eels. The research group has also found that other teleosts do not possess CNP4b gene, and that CNP4 compensates a function of CNP4b. This study sheds light on the scientifically hidden molecular evolution of the natriuretic peptide family and provides important data on the relationship between genetic diversification and functional differentiation.
Journal Name： Cell and Tissue Research (Published online on February 16, 2022）
Title: Gene duplication of C-type natriuretic peptide-4 (CNP4) in teleost lineage elicits subfunctionalization of ancestral CNP
Authors：Yukitoshi Katayama, Ami Saito, Maho Ogoshi, Yousuke Tsuneoka, Takao Mukuda,Morio Azuma, Makoto Kusakabe, Yoshio Takei, Takehiro Tsukada