The research group has previously reported that basic fibroblast growth factor (bFGF) reduces rat skin wound scarring. In the present study, a comprehensive analysis of rat skin fibroblasts treated with bFGF revealed that the identifying miR-146b-5p reduced the size of rat skin wound scars. miR-146b-5p was found to reduce scar size by suppressing the scar fibrosis through its targeting PDGFRαrepression in skin wounds. Moreover, miRNA146b-5p may suppress PDGFRα expression in adipose stromal cells, which will lead to suppression of the scar fibrotic potential of PDGFRα in adipose tissue.
The findings from this study will not only elucidate the mechanism of adipose tissue-mediated scar fibrosis in skin wounds, but also may prevent dysfunction caused by organ fibrosis by suppressing scar fibrosis in damaged organs via miRNA146b-5p administration.
Journal of Investigative Dermatology (Published on-line: December 18, 2021)
The role for miRNA146b-5p in the attenuation of dermal fibrosis and angiogenesis by targeting PDGFRα in skin wounds
Chie Fujisawa, Makoto Hamanoue, Yayoi Kawano, Daiki Murata, Yuri Akishima-Fukasawa, Tetsuya Okaneya, Takeo Minematsu, Hiromi Sanada, Kayo Tsuburaya, Takuma Isshiki, Tetuo Mikami, Takehisa Hanawa, Yoshikiyo Akasaka* (*Responsible author)