Dr. Yasuaki Tatsumi of Toho University School of Pharmaceutical Sciences and Prof. Koichi Kato of Aichi Gakuin University School of Pharmacy and their research group had previously reported that docosahexaenoic acid (DHA) induces antioxidant enzymes and protects Schwann cells from oxidative stress-induced cell death.
However, the relationship between autophagy and oxidative stress-induced cell death, thought to be closely related to oxidative stress — one of the major causes of diabetic neuropathy, remained unclear.
In this study, they investigated the relationship between DHA and autophagy on oxidative stress-induced cell death using rat immortalized Schwann cell line. The results showed that pre-administration of DHA suppressed oxidative stress-induced cell death, and as a mechanism, suppressed autophagy signaling induced by oxidative stress. This suggests that DHA may inhibit cell death of Schwann cells by regulating autophagy induced by oxidative stress, in addition to the induction of antioxidant enzymes as reported previously.
International Journal of Molecular Sciences, April 15, 2022 issue, Volume 23 No.8, 4405
Docosahexaenoic Acid Suppresses Oxidative Stress-Induced Autophagy and Cell Death via the AMPK-Dependent Signaling Pathway in Immortalized Fischer Rat Schwann Cells 1
Yasuaki Tatsumi, Ayako Kato, Naoko Niimi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Hideki Kamiya, Jiro Nakamura, Koji Higai, Kazunori Sango, Koichi Kato