A healthy gut microbiome is essential for intestinal homeostasis however
mechanisms underlying regulation of intestinal bacteria by intestinal epithelial cells remain unclear. In this study, investigation of genetically engineered mice revealed the role of IκBζ, a transcriptional regulator, which regulates the antimicrobial activity of epithelial cells via the interleukin (IL)-17 cytokine primarily released by Th17 cells (lymphocytes that constitute intestinal immune cells). Optimal maintenance of intestinal bacteria via modulation of IκBζ function and IL-17 signaling may serve as potential novel treatment for excessive immune response-mediated diseases.
Mucosal Immunology August 24 2022 issue
IκBζ controls IL-17-triggered gene expression program in intestinal epithelial cells that restricts colonization of SFB and prevents Th17-associated pathologies.
Soh Yamazaki*, Naohiro Inohara, Masaki Ohmuraya, Yousuke Tsuneoka, Hideo Yagita, Takaharu Katagiri, Takashi Nishina, Tetuo Mikami, Hiromasa Funato, Kimi Araki, Hiroyasu Nakano*