PhD Programs in Medicine


We offer a diverse range of research areas within the Graduate School of Medicine. To help you identify a supervisor related to your research area you may like to explore the research interests of our academic staff.

Metabolic Control System

Supervisor(s)Research areas/topics
Prof. Atsuhiko Naito, MD, PhD1. Elucidation of the biological system specific to non-mitotic cells
2. Systems biology of the mechanism of cell-fate decision  (differentiation, senescence, cancer transformation, and cellular death)
3. Drug discovery using human iPS-derived cardiomyocytes
4. Molecular mechanism for circadian clock; physiological & medical roles
5. Chrono-adaptation systems synchronously responding to environmental stresses
6. Mathematical modeling of the mechanisms involved in cardiovascular    toxicity associated with cancer treatment
7. Elucidation of the molecular networks involved in anti-cancer drug resistance
 Supervisor(s)Research areas/topics
Prof. Hiroyasu Nakano, MD, PhD1. Elucidation of a role for cell death in maintaining tissue homeostasis
2. Generation of various murine disease models triggered by enhanced cell death
3. Elucidation of the mechanisms underlying necroptosis
4. Elucidation of the mechanisms underlying non-alcoholic steatotic hepatitis
5. Live cell imaging of necroptosis by a FRET biosensor, SMART
6. Research on interleukin 11-producing fibroblasts in the development of colorectal cancer
Currently not open
 Supervisor(s) Research areas/topics
Prof. Atsushi Sugiyama,MD, PhD 1. Development of prediction system for drug-induced long QT syndrome
2. Research on therapeutic target of persistent atrial fibrillation
3. Application study of microminipig for a model animal of cardiovascular diseases
4. Research on therapeutic strategy against the diastolic heart failure
5. Research on the impacts of cardiopulmonary resuscitation devices on mechanophysiology and pathopharmacology
6. Research on cardiac safety pharmacology of anti-cancer drugs
 Supervisor(s) Research areas/topics
Prof. Takanori Ikeda,MD, PhD 1. Prediction and Prevention of Sudden Cardiac Death Using Electrocardiographic Markers
2. Electrophysiological Study Regarding Mechanisms on Occurrence of Tachyarrhythmias
3. Clinical Effect of Pharmacotherapy and Catheter ablation in atrial fibrillation
4. Clinical Pharmacological Research Regarding Efficacy of Cardiovascular Medicines
5. Clinical Assessment of Catheter Techniques and/or Implantable Devices in Cardiology
6. Clinical Evaluation Regarding Interventional Treatment in Coronary Artery Disease
7. Assessment Regarding Pathology and Treatment in Heart Failure and/or Pulmonary Hypertension
8. Assessment of Cardiovascular diseases Using Cardiac Imaging Modalities
9. Prognosis of Deep Venous Thrombosis and Pulmonary Thromboembolism
Prof. Masao Moroi, MD, PhD 1. Development of precisional simulation for atherosclerotic lesion progression using noninvasive image modalities in an individual patient
2. Development of an animal model of cardiac sarcoidosis and innovative image modalities for diagnosis and therapeutic approach in patients with cardiac sarcoidosis
3. Clarification of atherosclerotic progression process in insulin resistance and development of therapy based on the mechanisms
4. Elucidation of mechanisms and development of treatment for left ventricular diastolic dysfunction associated with myocardial energy metabolism
5. Clarification of the process of cardiac lesions in Fabry disease and new approach for the therapy
6. Establishment of comprehensive and complete profiling of national burden of non-communicable disease risk factors; differences between Bangladesh and Japan
7. Clarification of the mechanisms of heart failure progression caused by chronic inflammation
8. Development of new therapies for disorders of organs in diabetic obese and metabolic syndrome focused on intestinal flora
9. Evaluation of the action of a SGLT2 inhibitor in type 1 diabetes model mice
10. Development of new therapeutic agents for heart failure targeting mitochondria
 Supervisor(s) Research areas / topics
Prof. Takahisa Matsuda, MD, PhD 1. Research on diagnosis and treatment for gastrointestinal cancers
2. Research on diagnosis and treatment for bilio-pancreatic diseases
3. Research on diagnosis and treatment for liver diseases
4. Research on recurrence of common bile duct stones
5. Research on inflammatory bowel disease
6. Research on gastrointestinal motility
7. Research on Helicobacter pylori
8. Research on peptic ulcer
9. Research on gastrointestinal cancer screening
10. Research on the development of endoscope-related equipments
Prof. Katsuyoshi Matsuoka, MD, PhD 1. Studies utilizing prospective cohorts of patients with inflammatory bowel disease
2. Studies on the therapeutic effects of drugs for inflammatory bowel disease
3. Studies on the pathogenesis of inflammatory bowel disease
4. Studies on the search of biomarkers in inflammatory bowel disease
 Supervisor(s) Research areas/topics
Prof. Hideaki Shimada, MD, PhD 1. esophageal surgery, gastric surgery
2. surgical oncology
3. chemotherapy
4. immunotherapy
5. molecular therapy
6. biomarker
Prof. Kimihiko Funahashi, MD, PhD 1.Colorectal cancer
 ⑴ Minimally invasive surgery
  • Transanal approch for rectal cancer
 ⑵ Intersphincteric resection
 ⑶ Low anterior resection syndrome
  • Survey of Japanese patients with major LARS
  • Team approach for patients with LARS
 ⑷ Malignant bowel obstruction
  • Mechanism of distant metastasis in malignant bowel obstruction
 ⑸ Chemotherapy for stage IV CRC / unresectable CRC
  • Predictive markers
2.Rectal prolapse
 ⑴ What’s the best choice for RP;Development of new technique
 ⑵ Analysis of mechanism of RP
3.Surgical site infection
 ・ Mechanism of wound healing in negative pressure wound therapy
4.Complication of ileostoma
 Prof.Yuichiro Otsuka, MD, PhD 1.Research on improvement of surgical outcome for Hepatocellular carcinoma
2.Research on improvement of surgical outcome for Metastatic tumor from Colo-rectal cancer
3.Research on standardization of minimally invasive surgery for liver disease
4.Research on improvement of surgical outcome for Biliary cancer
5.Research on standardization of minimally invasive surgery for Biliary disease
6.Research on improvement of surgical outcome for Pancreatic cancer
7.Research on standardization of minimally invasive surgery for Pancreatic disease
Prof. Yoshihisa Saida, MD, PhD 1. Digestive Surgery: Stomach, Small Intestine, Colon and Rectum, Surgical Treatment and Chemotherapy of Colorectal Cancer
2. Minimal-invasive treatment: endoscopic treatment, laparoscopic surgery, laparoscopy endoscopy combination surgery
3. Digestive endoscopy: Digestive endoscopy diagnosis, endoscopic treatment, colonic stent, intraoperative endoscopy
4. Infectious disease: postoperative infection, antibacterial therapy, nosocomial infection
5. Non-smoking instruction
Prof. Manabu Watanabe, MD, PhD 1. Hepato-Biliary-Pancreatic surgery
2. Endoscopic surgery, Reduced port surgery
3. Postoperative infection: Surgical site infection, Remote infection, Perioperative infection control
4. Surveillance of infectious complications following gastroenterological surgery
5. Laparoscopic cholecystectomy for acute cholecystitis
6. Metagenomic analysis for acute cholangitis
7. Multimodal imaging of cancerous regions utilizing spectral X-ray CT and 7T-MRI
 Supervisor(s) Research areas/topics
Prof.Takeshiro Fujii, MD, PhD 1. New device of frozen elephant trunk for thoracic aortic disease
2. Preventing method to cerebral injury of total arch replacement for acute aortic dissection
3. Antibacterial Effects of Vascular Grafts Treated with Rifampicin, Colistin, Vancomycin, or Daptmycin
4. Risk analysis of acute type B aortic dissection: Experience of Tokyo Acute Aortic Super-network
5. Comprehensive strategy of the blood transfusion therapy during the congenital heart surgery
6. To launch the medical department of adult congenital heart disease utilizing cardiac MRI
7. Analysis of non-invasive sutureless valve for aortic valve disease
8. Evaluation Trial Clinical Economics of IMPELLA Circulatory Assist Pump Catheter
9. Analysis of no-touch saphenous vein graft structure for coronary aorta bypass grafting
Prof.Shigeyuki Ozaki,MD, PhD 1. A study on the durability of aortic valve reconstruction using autologous pericardium
2. Pathophysiological investigation of the calcification in biological valves
3. Pathological study of calcification in valves of dialysis patients
4. Development of affordable heart assist device through medicine and engineering collaboration
5. Infection unique to the field of cardiovascular surgery and treatment strategy
6. Development of new device for aortic valve reconstruction surgery
Prof.Noboru Motomura, MD, PhD 1. Prevention of post operative arrhythmia, especially atrial fibrillation
2. Vascular function research in cardiovascular surgery estimated by CAVI (cardio ankle velocity index)
3. Improvement of cardiovascular surgery outcome by the intensive control of blood glucose using the artificial pancreas
4. Development of new device for cardiovascular surgery
5. Prevention of spinal cord paralysis by an oral medication
6. Research in improvement of endothelial function through cardiovascular surgery
7. Diabetic retinopathy and ischemic heart disease
 Supervisor(s) Research areas/topics
Prof.Masahiko Nakata, MD, PhD 1. Study of evaluation for fetal cardiac function
2. Study of pathological mechanism in twin-to-twin transfusion syndrome
3. Research and development of new surgical equipment for fetal therapy
4. Research on Autonomic Neuropathy in Pregnant Women
5. Study of pathological mechanism in fetal growth restriction
6. Study of organ development and the dysfunction in the human fetus
7. Study for maternal cardiovascular dynamics in pregnancy
Prof.Yukiko Katagiri, MD, PhD 1. Influence of environment of early embryo on epigenetics
2. Effects of luteinizing hormone on implantation
3. Immune response and implantation
4. Intrapelvic environment with endometriosis for fertility
5. Placenta formation and reproductive medicine
6. Study for oncofertility
Prof. Kyoko Tanaka, MD, PhD 1. Analysis of early genes in HPV maintenance replication
2. Functional analysis of low-risk HPV and high-risk HPV for p53
3. The relationship between prognosis of CIN2 and expression of HPV E4
4. Study on the effectiveness of laser vaporization for CIN3
5. Study on the safety of radical trachelectomy for early stage of cervical cancer
 Supervisor(s) Research areas / topics
Prof. Toshisuke Morita, MD, PhD 1. Functional food and anti-aging medicine
2. Role of uremic toxins on cardio-renal syndrome
3. Tissue transplantation using amnion
4. Research on new diagnostic methods, treatment and prognosis of syphilis
5. Elucidation of the Mode of Clostridioides difficile pathogenesis and  Transmission Based on One Health Approach
6. Pursuing the pathophysiology, diagnosis, treatment, and prognosis of Streptococcal Toxic Shock Syndrome.
 Supervisor(s) Research areas/topics
Prof. Yoshihisa Urita, MD, PhD 1. General medicine as a complex systems science: mathematical model of clinical practice
2. Mathematical analysis for transmission of infectious diseases
3. Biochemical study for glucose metabolism of cancer cells
4. Fractal analysis of ultrasound imaging in lymph node, thyroid, and liver diseases
5. Biogas analysis of skin gas during haemodialysis therapy
6. Study on relationship between arrhythmia and gastrointestinal motility
7. Study on gastrointestinal function: digestion, absorption, motility, bile acids, vitamins, and minerals
8. Effects of alcohol intake and diabetes on cognitive function
9. Ketone bodies as a biomarker of prostate cancer
10. Cardiac function demonstrated in still image of echocardiogram
Prof. Mitsuru Honda, MD, PhD 1.Development of training system for emergency care
2.Brain function evaluation research by non-invasive monitoring for patients with severe brain injury
3.Quantitative brain function evaluation and outcome prediction study of septic encephalopathy
4.Developmental research on quantification and visualization of lung ventilation
5.Research on the usefulness of rapid electroencephalogram for the treatment of consciousness disorder in ER
 Supervisor(s) Research areas/topics
Prof. Ken Sakai, MD, PhD 1. Nutrition for Renal Patients: Visceral Fat Accumulation on CT and Bioelectrical Impedance Analysis (clinical study)
2. Peritoneal Function and Pathology for Patients with PD/HD Combination Therapy (clinical study)
3. Study for Renal Transplant Recipients/Donors: Biopsy based Long-term Prognosis and Recurrence Nephritis (clinical study)
4. CNI Renal Toxicity Analysis and Periodical Renal Biopsy Findings on Newly Developed Immunosuppression (clinical study)
5. Nutritional Status for Patients with Low-Protein-Diet Regimen (clinical study)
6. Dialysis Reintroduction after Renal Transplantation: Patents Characteristic and Prognosis (clinical study)
7. Growth in Children with Renal Failure after Renal Transplantation (clinical study)
8. IL6 Antibody for Chronic Antibody Mediated Rejection in Rats (experimental study)
9. Proliferative T cell profile analysis of graft interstitial tissue with acute antibody mediated rejection (Clinical study)
10. Regeneration change of tubular epithelial cell in kidney graft -analysis of protocol biopsy-(Clinical study)
Prof. Nobuhiko Joki, MD, PhD 1.Iron deficiency and uremic specific cardiomyopathy
2.Different influences of uremic milieu on the progression of atherosclerosis in three major coronary branchies.
3.Disturbance of oygen supply and demand in myocardium of uremic  patients
4.Pathogenesis of kidney disease specific non-ischemic cardiomyopathy and heart failure
5.Vulnerability of fatal arrhythmia at the initiation of dialysis
6. Association of severity of atherosclerosis with stroke in CKD patients with atrial fibrilation
Prof. Yasushi Ohashi, MD, PhD 1.The manegements of kidney and health at different stage in life on patents with chronic kidney diease
2.The association of body fluid imbalance with reserve capacity for fluid accumulation on patients with chronic kidney disease
3.The association of calcium mass balance with vascular calcification on hemodialysis patients with Malnutrition-Inflammation Complex Syndrome
4. The research and development of quantitative assessment for dry-weight on patients undergoing hemodialysis
5. The research and development of DRY-weight scoring system based on Fluid Imbalance-associated clinical eighT signs in patients undergoing hemodialysis (DRYFIT)
 Supervisor(s)Research areas / topics
Prof. Hideaki Shimada, MD, PhD1. medical oncology
2. surgical oncology
3. radiation oncology
4. palliative medicine
5. oncological diagnosis
Prof. Yoichi Nakamura, MD, PhD1. Research on prognosis of cancer patients
2. Research on quality-of-life measures of cancer patients
3. Research on end-of-life care
4. Research on spiritual pain and communication

Integrative Biosystem

 Supervisor(s)Research areas/topics
Prof. Fumi Sato, MD, PhD1. Morphological analysis of the neural circuit controlling the motor system
2. Anatomical study of the cardiac regulation system
3. Functional neuroanatomical research of the local retinal circuits creating visual functions
 Supervisor(s)Research areas/topics
Prof. Hiromasa Funato, MD, PhD1. Functional neuroanatomy for sleep/wakefulness
2. Molecular mechanism regulating sleep/wakefulness
3. Functional neuroanatomy of the preoptic area
4. Neural circuitry regulating innate behaviors
 Supervisor(s)Research areas/topics
Prof. Satomi Adachi-Akahane, MD, PhD1. Integrative and systems physiology of regulatory mechanisms underlying homeostasis of cardiac function: Elucidation of the molecular basis of regulation via an inter-organ network consisting of heart-digestive system-adipose tissue-kidney- skeletal muscle-autonomic nerve-axis
2. Pathophysiology of heart disease caused by metabolic dysregulation: Elucidation of mechanisms underlying failure in the homeostatic regulation of cardiac function due to dyslipidemia and diabetes
3. Molecular basis of sensing and regulation of organ function: Elucidation of the mechanism of sensing and regulation of organ function and sensation focusing on voltage-gated calcium channel
4. Molecular mechanism of lipid metabolism regulation through lipid transportsome: Elucidation of mechanisms involved in the regulation of intracellular lipid storage and its failure that leads to the onset of disease such as NASH
5. Systems physiology of fine-tuning of cell signaling dynamics involved in the above listed 1 to 4 by use of molecular imaging and computational science.

Currently not available

 Supervisor(s) Research areas / topics
Prof.Osamu Kano, MD, PhD 1. Identifying the new biomarker in neurodegenerative disease
2. Identifying the pathogenesis of ALS
3. Robot-assisted training using Hybrid assistive Limb for neurodegenerative patients
4. Analyzing the cerebral infarction in three dimensions
5. New functional rating score for primary lateral sclerosis patients
6. Development the new diagnostic tool using artificial intelligence
Prof. Ryuji Sakakibara, MD, PhD 1. Cerebrospinal fluid & serum biomarkers in Alzheimer’s disease and Parkinson’s disease
2. Cerebrospinal fluid oxidative stress in neurodegenerative diseases and stroke for advanced tailor-made therapies
3. Analysis of autonomic dysfunction in neurodegenerative diseases  for developing future drug treatment
4. Cerebrospinal fluid alpha-synuclein in Parkinson’s disease and multiple system atrophy
5. Central Ca channel blockers for spinocerebellar ataxia 6
6. Preventing CNS alpha-synuclein aggregation in multiple system atrophy
7. Advanced neuroimaging markers in neurodegenerative diseases
 Supervisor(s) Research areas / topics
Prof. Nobuo Sugo, MD, PhD 1. Study of nuclear medicine for diagnosis of brain tumors
2. Study of surgical approach to skull base tumor
3. Study on hardness of brain tumor
4. Study on 3D fusion image of brain
5. Study on endovascular surgery for cerebral aneurysm
6. Study of surgical treatment for carotid artery stenosis
7. Study of neurosurgical simulation
8. Study of brain disease using rapid prototyping model by 3D printer
9. Study of intraoperative cerebral blood flow using laser speckle flowgraphy (LSFG)
10. Molding of 3D model for neuroendoscopic surgery and surgical practice
Prof. Satoshi Iwabuchi, MD, PhD 1. Signal transduction in vasospasm following subarachnoid hemorrhage
2. Mechanism of drug resistance in murine glioma stem cell model
3. Notch pathway activation in glioma
4. Physical evaluation of catheters used for Interventional Neuroradiolgy
5. Change in flow dynamics after intra-arterial infusion therapy for vasospasm
6. Retinal circulation before and after carotid artery stenting
7. Sports related head injury and concussion
8. Hemodynamic evaluation using computational fluid dynamics (CFD) for the development of carotid plaque
9. The utility of Radiofrequency neurotomy for sacroiliac joint dysfunction
10. Analysis of the patient treated with mechanical thrombectomy in the medical area
11. Clinical study of Botulinus Toxin Therapy for post stroke pain
Prof. Masaaki Nemoto, MD, PhD 1. Study of subarachnoid hemorrhage with an intracereberal hematoma
2. Study of subarachnoid hemorrhage in the elderly patients
3. Study of germinal matrix hemorrhage in extremely low-birth-weight infant
4. Clinical study of intracranial hypotension syndrome
5. Study of deep brain stimulation(DBS) for Parkinson’s disease
6. Study on the development of delirium in neurosurgical disease
 Supervisor(s)Research areas / topics
Prof. Hiroshi Takahashi, MD, PhD1. Study on the mechanism of development of low back pain
2. Study on quantitative evaluation of surgical stress
3. Regenerative medicine of bone and cartilage
4. Study on the diagnosis and treatment of articular infectious disease
5. Study on low-invasive spinal surgery
6. Study on a new treatment method for spinal canal stenosis
7. Study on the development of new treatment method for spinal deformity 
8. Study on the cause of ossification of the posterior longitudinal ligament
9. Elucidation of the pathology of osteoporosis
Prof. Yoshiro Musha, MD, PhD1. The study of the development of artificial joints for limb joints
2. The evaluation of limb function and treatment in sports injuries
3. The study for the function and reconstruction of shoulder, elbow, wrist joint, fingers
4. The study of the pathology, treatment and reconstruction of hip, knee and ankle diseases
5. The study of the pathology of pain from spinal cord or vertebra, evaluation method, and treatment
6. New evaluation method of neurological severity of cervical myelopathy and lumbar canal stenosis
7. Treatment of bone soft tissue tumor, functional reconstruction after removal, bone and cartilage regeneration
8. Development and evaluation of minimally invasive surgery for orthopedic disease
9. Development of new biomaterials and implants
10. Elucidation of the pathology of osteoporosis, drug treatment and surgical therapy for vertebral fracture
Prof. Hiroyasu Ikegami, MD, PhD1. Research on function and reconstruction of the hand
2. Research on function and reconstruction of the elbow
3. Research on function and reconstruction of the shoulder
4. Research on pathology and treatment for rheumatoid arthritis
5. Regenerative medicine of bone and cartilage
6. Regenerative medicine of muscle and tendon
7. Research on regeneration and reconstruction of the peripheral nerve
8. Research on bone metabolism and osteoporosis
9. New approaches for the control of musculoskeletal pain
10. Development of new biomaterials
Prof. Koichi Nakagawa , MD, PhD1. Research on pathology and treatments of rheumatoid arthritis
2. Development of a newly designed-artificial knee joint
3. Research on regenerative medicine for articular cartilage
4. Molecular biological research of articular cartilage metabolism
5. Research on surgical treatments of ligament injures of the knee
6. Research on minimal invasive spinal surgeries
7. Research on the mechanism of joint pain and its assessment tools
8. Research on bone metabolism and osteoporosis
9. Research on diagnosis and treatments of spinal cord injury
 Supervisor(s)Research areas / topics
Prof. Akihiro Ogino, MD, PhD1. Research on intractable wound treatment
2. Evaluation by blood flow visualization and digitization in flap reconstructive surgery
3. Intraoperative repositioning assessment using navigation system in facial fracture
4. Evaluation of navigation-assisted bone osteotomy for malunited fracture
5. Verification of the timing of distant flap separation by longitudinal evaluation of blood flow 
6. Research on the negative pressure wound therapy
Prof. Akiteru Hayashi,MD, PhD1. Anatomic study of vasculature and nerve supply of flaps
2. Reconstruction of facial nerve paralysis: facial reanimation and evaluation
3. Reconstruction of extremities
4. Wound healing: skin ulcers, tissue transplantation
5. Blepharoptosis
6. Skin and soft tissue of temporal region
7. Interaction of mimic muscles and masticatory muscles
Currently not open
 Supervisor(s)Research areas/topics
Prof. Yoshimasa Takeda, MD, PhD1. Research on prognosis of surgical patients from preoperative risk
2. Study on prevention, mechanism, and treatment of postoperative delirium
3. Perioperative risk management clinical strategy
4. Development of risk assessment coding system in preoperative anesthesia outpatient department
5. Evaluation of non-invasive biological information monitoring system in surgical patients
6. Research on comprehensive pain assessment for spinal nerve stimulation therapy
7. Development of intraischemic hypothermia during cardiac arrest
Prof. Yoshifumi Kotake, MD, PhD1. Anesthetic protection against organ damage caused by ischemia
2. Development of non-invasive vital sign monitoring system
3. Development of novel perioperative fluid
4. Quantitative measurement of surgical stress using parasympathetic activity
5. Preoperative assessment of cardiorespiratory reserve in surgical patients
Prof.Takayuki Kitamura, MD, PhD1. Optimization of perioperative glycemic control in patients undergoing cardiac surgery
2. Optimization of anesthetic management for patients with inflammatory bowel disease
 Supervisor(s) Research areas / topics
Prof. Kota Wada, MD, PhD 1. Research for refractory rhinosinusitis
2. Research between function of sinus and sleep
3. Research for regeneration of nasal and sinus mucosa
4. Research for refractory rhinosinusitis using proteome analysis
Prof. Mamoru Yoshikawa, MD, PhD 1. Endotype classification of chronic rhinosinusitis for precision medicine
2. Development of a novel therapy for severe allergic rhinitis
3. Pathological analysis of allergic fungal rhinosinusitis
4. Development of a novel diagnostic method of obstructive sleep apnea syndrome
 Supervisor(s) Research areas/topics
Prof. Yuichi Hori, MD, PhD 1. Ocular Circulation and Systemic disease
2. Ocular surface barrier and homeostasis
3. New Diagnosis technology of Retinopathy of prematurity (ROP)
4. New Diagnosis technology of Ocular infection
5. Development of new device of Vitreoretinal surgery
6. Tear dynamics
7. Etiology of Uveitis
8. New Diagnosis technology of Glaucoma
Prof. Masahiro Ishida, MD, PhD 1. Study on retinal morphology and visual function in macular disease
2. Study on the mechanism of metamorphopsia
3. Development of new surgical technique and device for vitreoretinal surgery
4. Study on diagnosis of glaucoma
5. Study on three-dimensional image analysis of the fundus
6. Study on ocular blood flow
Prof. Takatoshi Maeno, MD, PhD 1. Research on surgical treatment for refractory vitreoretinal disease
2. Development and research of surgical instruments for vitreous surgery
3. Quantitative evaluation of surgery by measurement of ocular blood flow
4. Analysis of serum and vitreous LR11 in vitreoretinal disease
5. Research on the relationship between ophthalmic diseases and oxidative stress
6. Clinical studies on the relationship between systemic disease and automatic regulation of ocular blood flow

Currently not available


Biological Response

 Supervisor(s) Research areas / topics
Prof. Tetsuo Mikami, MD, PhD 1. Mechanism of carcinogenesis and cancer progression in chronic inflammation
2. Clinicopathological analysis and molecular pathology of human cancer
3. Stromal reaction in invasion and metastasis of carcinoma
 Supervisor(s) Research areas / topics
Prof. Kei Takahashi, MD, PhD 1. Analysis on pathogenesis of Kawasaki disease
2. Histopathological aspects on long term issues of the cardiovascular sequelae on Kawasaki disease
3. Pathological analysis on systemic vasculitis syndrome
4. Experimental analysis on developmental mechanism of vasculitis-induced animal model
5. Molecular pathology on the developmental mechanism for cardiovascular diseases
Prof. Nobuyuki Hiruta, MD, PhD 1. Research on diagnosis of bone and soft tissue tumors
2. Research on therapeutic evaluation of bone and soft tissue tumors
3. Research on automatic analysis for pathological digital images
4. Research on the accumulation of microplastics in human organs
 Supervisor(s) Research areas/topics
Prof. Kazuhiro Tateda, MD, PhD 1. Research for pathogenesis of infection and infectious diseases
2. Research for development of novel technologies in infectious diseases
3. Research for epidemiology and molecular mechanisms in antibiotic resistance
4. Appropriate choice and positioning of antibiotic chemotherapy
5. Strategic approach for infection control and prevention
6. Direction of new antimicrobials: past, present and future
 Supervisor(s)Research areas/topics
Prof. Motonari Kondo, MD, PhD1. Cytokine function during lymphocyte development
2. Regulation of immune response by cytokines
3. Molecular mechanisms of T-cell differentiation and acquisition of immune tolerance
4. The role of acetylation in  signaling molecules
 Supervisor(s)Research areas/topics
Prof. Kazuma Kishi, MD, PhD1. Research on cross talk mechanism between lung and gut microbiome in interstitial lung diseases
2. Research on factors contributing to the relapse of  acute exacerbation of idiopathic pulmonary fibrosis
3. Research on safety and usefulness of surgical lung biopsy in diffuse lung disease
4. Study on lncRNA in EGFR mutation positive non-small cell lung cancer
5. Study on biomarkers using circulating tumor cells in  lung cancer
6. Research on pathogenesis and treatment in sleep apnea syndrome
7. Research on adherence of Continuous positive airway pressure
8. Self-propelled catheter aiming at reaching the periphery of the lung
9. Study on therapeutic effect with subtype of exon19 deletion-positive non-small cell lung cancer
10. Study on hypoxia-inducing factors in lung cancer with interstitial pneumonia
Prof. Hiroto Matsuse, MD, PhD1. Research on pathogenesis and treatment for refractory pulmonary infectious diseases
2. Research on pathogenic mechanism and regulation of allergic airway inflammation in asthma
3. Research on pathogenic mechanism and regulation of peripheral airway obstruction in chronic obstructive pulmonary disease
4. Research on pathogenic mechanism and regulation of acute exacerbation in chronic airway inflammation caused by infection.
5. Research on pathogenesis and treatment of lung cancer
6. Research on epidemiology, diagnosis and treatment of chronic cough in adults
 Supervisor(s) Research areas/topics
Prof. Akira Iyoda, MD, PhD 1. Study on molecular target markers for treatments in patients with lung cancer
2. Study on large cell neuroendocrine carcinoma of the lung
3. Study on lung adenocarcinomas with micropapillary component
4. Study on treatments in patients with idiopathic pulmonary fibrosis
5. Study on prevention of postoperative complications in patients with COPD
6. Study on prognostic markers in patients with malignant pleural mesothelioma
7. Study on thymoma
Prof. Atsushi Sano, MD,PhD 1. Application of three-dimensional computed tomography in thoracic surgery
2. Application of ultrasonography in thoracic surgery
3. Study on the influence of respiratory function on the perioperative period
4. Study on perioperative respiratory rehabilitation
5. Study on devices in thoracic surgery

Currently not available


 Supervisor(s) Research areas/topics
Prof.Toshihiro Nanki, MD, PhD 1. Roles of chemokine in the pathogenesis of rheumatoid arthritis
2. Pathogenesis of interstitial pneumonia complicated with rheumatic diseases
3. Pathogenic role of adipokine in rheumatoid arthritis
4. Intestinal flora of rheumatic diseases
5. Pathogenesis of steroid-induced osteoporosis
6. Atherosclerosis in patients with rheumatoid arthritis
Prof. Hideto Kameda, MD, PhD 1. Elucidation of the pathogenesis of rheumatic diseases ~Over-response to micro-injury hypothesis~
2. Study of molecular biological changes during the relapse of rheumatic diseases
3. Study on the treatment of intractable rheumatic diseases
4. Study on the relationship between the pathophysiology and  images of arthritis
5. Enthesitis in spondyloarthritis and transcription factors

Currently not available

Prof. Hideaki Kanemura, MD, PhD1. Investigation of QOL-related factors in childhood epilepsy

 Supervisor(s)Research areas/topics
2. Investigation of cognitive and behavioral problems in childhood epilepsy
3. Investigation of rational polypharmacological therapy for childhood epilepsy
4. Analysis of EEG characteristics in neurodevelopmental disorders
5. Investigation of biomarkers in neurodevelopmental disorders
6. Investigation of novel therapeutic approach for neurodevelopmental disorders
7. Electrophysiological research in pediatric neurological diseases
8. Electrophysiological research in pediatric neurological diseases

Currently not available

 Supervisor(s)Research areas/topics
Prof. Akira Ishiko, MD, PhD1. Elucidation of the mechanism of blister formation in autoimmune bullous diseases
2. Development of a system to evaluate pathogenic activity of autoantibodies in  pemphigus sera
3. Investigation for multidisciplinary diagnosis of epidermolysis bullosa, and genotype-phenotype correlation
4. Pathological and ultrastructural analysis of skin tumors
5. Evaluation of the relationship of skin barrier function and irritation reaction in patch test
6. Surveillance of occupational skin disorders and causative allergens
7. Evaluation of positive rates of the patch test using the Japanese standard allergens; surveillance and disease-oriented evaluation
8. Detection of strong sensitizers in the household commodities and their cross reactive sensitization
9. Evaluation of metal allergy using patch test and lymphocyte stimulation test
10. Development of biomarkers indicating the disease activity and  the disease subtype of psoriasis
Prof. Tetsuya Higuchi, MD, PhD1. Mechanism of the aggravation of psoriasis by adipocytokines
2. Production of adipocytokines from subcutaneous tissue
3. Mechanism of skin eruption in autoimmune disease
4. Diagnosis of causative drug in patient with skin eruption
5. Analysis of skin eruption in inflammatory bowel disease
6. Comparison of ultrasonic image and histology in skin disease
7. Comparison of dermoscopy finding and histology in skin disease
8. Analysis of foot function in patients with epidermolysis bullosa simplex
9. Proteomic analysis of loquat allergens
 Supervisor(s)Research areas / topics
Prof. Koichi Nakajima, MD, PhD1. Development of the new biomarker for renal cell cancer
2. Basic research for erectile dysfunction and epidemiological survey relationship between life-style disease and erectile dysfunction
3. Development of the simple and easy objectivity evaluation method for erectile function
Prof. Koichi Nagao, MD, PhD1. Basic and clinical research for reproductive medicine
2. Males sexual dysfunction
3. Clinical study for Peyronie’s disease
4. Pediatric urology
5. Genital reconstructive surgery
6. Microsurgery
7. Urethral stricture
8. Pelvic organ prolapse
Prof. Noritoshi Sekido, MD, PhD1. Clinical research on urological cancers
2. Physiological research on lower urinary tract function
Prof. Hiroyoshi Suzuki, MD, PhD1. Search for novel biomarkers in urological tumors
2. Elucidation of hormone refractory molecular mechanism of prostate cancer and therapeutic development
3. Development of predictive system for adverse events and prognosis of prostate cancer
4. Development of predictive models for clinical/pathological outcome of endoscopic surgery
5. Development of new equipment contributing to navigation and safety  improvement of laparoscopic surgery
6. Neurophysiological studies on urinary voiding function
7. Investigation of postoperative biological change after the surgery for adrenal tumors
8. Development of novel graphic model in urological tumors
 Supervisor(s)Research areas/topics
Prof. Masaaki Hori, MD, PhD(Diagnostic imaging) 
1. Assessment of perfusion and ventilation using dual energy CT for patients with COPD, Interstitial Pneumonitis Assessment of perfusion using Lung PBV (perfused blood volume imaging) for patients with Pulmonary Thromboembolism Assessment of calcification elimination method in coronary artery CT study Assessment of coronary calcium score
2. Detection of early colon cancer using CT Colonography CT Gastrography with Dual Source Dual Energy CT: Diagnosis of Gastric Cancer with Three-dimensional Imaging and Two-dimensional Iodine Map
3. Evaluation of carpal tunnel syndrome and sciatic nerve using MR neurography
4. Evaluation of degenerative disease using advanced diffusion MR imaging  Evaluation of neural tissue by using quantitative MR imaging Assessment of neuropsychiatric disorder and cerebral morphology
5. Evaluating the usefulness of fusion image in collaboration with nuclear medicine
(Nuclear medicine)
1. Development and improvement of diagnosis method of brain disease with integrated image statistics analysis including nuclear medicine image and MRI
2. Dynamic and static study of lung perfusion scan in idiopathic/hereditary pulmonary arterial hypertension
3. The usefulness of 18F-FDG PET for detecting interstitial pneumonia
Prof. Atsuro Terahara, MD, PhD(Radiation oncology)
1. Evaluation and optimization of dose distribution in high-precision radiotherapy
2. Acquisition and utilization of images for treatment planning in radiotherapy
3. Development and improvement of information system in radiotherapy
Prof.Tatsuya Gomi, MD, PhD1. Clinical research on abdominal imaging
2. Basic and clinical research on side effects of iodine contrast material
3. Research on new sequence of MRI
4. Research on new diagnostic method using workstation
Prof. Hitoshi Terada, MD, PhD1. Neuro-imaging (Neuroradiology, Neuro-nuclear medicine)
2. Cardiac imaging (Cardiac CT, Cardiac MRI, Cardiac nuclear medicine)
3. Musculoskeletal radiology
4. Pediatric radiology
 Supervisor(s)Research areas/topics
Prof. Ayano Inui, MD, PhD1. Hepatology for growth and health
2. Gastroenterology for growth and health
3. Research on the mechanism of liver and metabolism
4. Research on liver transplantation
5. Research on transitional medicine
6. Research on mother-to-child transmission

Socio-Environmental Medicine

 Supervisor(s)Research areas / topics
Prof. Kunihiko Kurosaki, MD, PhD1. Individual identification based on the DNA polymorphism
2. Genetic analyses of the human bone excavated from ancient remains
3. Medicolegal study of infectious diseases
4. Forensic pathology of sudden death from natural causes
5. Forensic toxicology of interaction of medical substances
 Supervisor(s)Research areas / topics
Prof. Yuji Nishiwaki, MD, PhD1. Environmental epidemiology
2. Nutritional epidemiology
3. Social epidemiology
4. Life-course epidemiology
5. Epidemiology on aging
6. Clinical epidemiology, study of intractable disease
7. Study on occupational health
8. Development of mobile sensing device to measure personal light exposure

Currently not available

 Supervisor(s)Research areas / topics
Prof. Tomonori Hasegawa, MD, PhD1. Health policy; basic concepts and case studies
2. Health economy; Technology assessment, Universal Health Coverage, Long term care insurance, etc.
3. Healthcare quality, patient safety, hospital accreditation; Performance measurement using clinical indicators, clinical guidelines, clinical pathway, etc.
4. Healthcare information management; information technologies on healthcare and information management
 Supervisor(s)Research areas / topics
Prof. Yoshitaka Murakami, MD, PhD1. Biostatistics for clinical research (clinical trials)
2. Meta-analysis of Individual Participants Data
3. Statistical Methods for infectious surveillance data
4. Calculation method in healthy life expectancy

Currently not available

 Supervisor(s)Research areas / topics
Prof. Naoki Hiroi, MD, PhD1. A course of action for future PBL tutorial (examination of valid educational method)
2. Verification of the usefulness of multidisciplinary cooperation education with clinical ethics education
3. Examination on evaluation for active learning (Learning’s evaluation and educator evaluation)
4. Way to reduce the burden of patient consultation service personnel
5. Verification of various problems in simulated patient training
6. Studies of effective education methods such as medical ethics, research ethics and clinical ethics
7. Development and evaluation of Interprofessional Education
8. Development and evaluation of effective lesson strategies
 Supervisor(s)Research areas / topics
Prof. Takahiro Nemoto, MD, PhD1. Mental health and early intervention in the community-based integrated care system
2. Cognitive rehabilitation for schizophrenia
3. Foreign residents’ mental health in Japan
4. Perinatal mental health
5. Psychotherapy such as Morita Therapy and Cognitive Behavior Therapy
6. Biological approach to early psychosis
7. Suicide prevention
8. Mental health in Adolescents and Young Adults
9. Implementation science in psychiatry
10. Organic mental disorders
Prof.Shuichi Katsuragawa, MD, PhD1. A research of various kinds of life support for the elderly living in community
2. A clinical research for psychiatric issues concerning the obesity
3. A clinical research of treatment program for the neuro-developing disorders among re-work program
4. A research for psychiatric issues concerning the renal failure
 Supervisor(s)Research areas/topics
Prof. Masahiro Hashizume, MD, PhD1. Somatosensory Amplification in Migraine
2. The Cognition of Catastrophizing in Migraine
3. Stress Coping in Medication Overuse Headache
4. Depression among Community-dwelling Older Japanese Adults
5. Cerebral Near-Infrared Spectroscopy and Neuroimaging of Eating Disorder
6. Cognitive and Behavioral Therapy for Depression with Absences from Work

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